List of Fatal Autoimmune Diseases – Learning Drives

There are more than 100 autoimmune illnesses which means that in the vast most cases they aren’t life-threatening. There are diseases that could be fatal or result in life-threatening complications.

Giant Cell Myocarditis

Giant cell myocarditis can be described as a rare condition of the cardiovascular system that can progress rapidly and often ends in death. 1

In this type of disease there is inflammation in the muscle of the heart (myocardium). Initial signs may include:

  • Fatigue
  • Breathing shortness
  • The ankles are swelling
  • Chest pain
  • Heart palpitations

Heartbeat irregularities (arrhythmias) may cause lightheadedness and loss of awareness. The time period from beginning of symptoms to the onset of complications that could lead to death or require the transplant of a heart is five and a quarter months.

Both genders can be affected by myocarditis with giant cells, this condition is able to strike at any time. The majority of the time, the condition occurs in middle or young individuals with the aged of about 42. The disease is not a common illness with about 300 cases reported in the journal.

There is no treatment for myocarditis with giant cells. 2

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Anti-NMDA Receptor Encephalitis

Anti-NMDA ( N-methyl-D-aspartate) receptor encephalitis was first recognized as a neurologic disease in 2007. In this autoimmune disorder that causes inflammation, the immune system makes antibodies that target NMDA receptors that are found in the brain. These receptors are essential to memory. The antibodies block signaling and result in swelling of the brain, called Encephalitis. Certain patients also develop cancers elsewhere in the body, which are linked with the condition, most often ovarian teratomas in women.

The most common affliction is among younger people, and is more frequent in females.

Anti-NMDA receptor encephalitis may cause various symptoms. The disease is most often seen to manifest with symptoms that are not as serious and will progress quickly until it is time to seek hospitalization.

Common symptoms are:

  • Changes in behavior (aggression or paranoia)
  • Probleme with cognition
  • Memory problems
  • Speech problems
  • The loss of consciousness
  • Unusual movement of the face or mouth, arms and legs
  • Seizures

While most cases of encephalitis triggered by the anti-NMDA receptor can be treated with a complete recovery, in some instances it could be fatal. It is estimated that about 6 percent of patients are killed by an encephalitis that is anti-NMDA. 3

Treatment options differ, but usually require a combination of tumor removal (if necessary) and steroids, plasma exchange or an intravenous immunoglobulin. 4

Mixed Connective Tissue Disease

Mixed connective tissue disorder (MCTD) can be an uncommon condition that may cause inflammation and pain in many joints. It is more common among women who are younger than 30 years old. MCTD is a syndrome of overlap which includes features of lupus as well as systemic sclerosis and polymyositis. However, the symptoms of rheumatoid arthritis as well as Sjogren’s syndrome may also be observed.

Aspects and signs could be:

  • Muscle weakness
  • Fever
  • Fatigue
  • A build-up of fluid in your hands, leading to puffiness
  • Rashes
  • Eyelids with a violet color
  • Hair loss
  • Kidney disease
  • Dysfunctions in the esophagus

The treatment for MCTD isn’t available. MCTD However, treatment options may help alleviate the symptoms of the disease. The use of over-the-counter remedies can alleviate joint pain and the inflammation of muscles. The use of glucocorticoids is possible when complications arise, or when flare-ups of the disease. A few people with MCTD may have to take long-term immunosuppressants.

The general prospects for people living with MCTD is positive. But, it varies depending on the symptoms that are present. Some patients will experience symptoms-free times that last for years and do not require treatment. The 10 year survival rate is around 80 percent, however with treatment, the condition may worsen in around 13 percent of cases. In the most serious instances, the disease could lead to fatal complications within 6 to 12 years from the onset. 5

Autoimmune Vasculitis

Vasculitis is a condition that causes inflammation and narrowing of blood vessels which include veins, arteries, and capillaries. Blood vessels play a role in transporting fluid between your heart as well as various organs of the body.

In this condition the immune system mistakenly attacks blood vessels, mistakenly believing they as an intruder, such as bacteria or viruses. Vasculitis can occur in isolation or alongside rheumatoid arthritislupus, or Sjogren’s syndrome.

The signs and symptoms can be different and depend on the organs involved as well as their severity. illness. Although some individuals will have minor symptoms, others may become extremely ill. The most common symptoms are the loss of weight, fever and appetite loss, generalized fatigue and discomforts.

Specific symptoms that are specific to specific organs within the body may be a result of the following.

  • Lungs Bloody coughing and shortness of breath
  • The GI tract Mouth sores, stomach discomfort. In the most severe cases, blockages or ruptures in the intestinal tracts
  • The ear, the throat sinuses, and nose: Chronic middle-ear infections Hearing loss, chronic middle-ear infections
  • Eyes Itching, redness sensitive to light blurred vision and, in rare instances blindness
  • The brain: Headaches, problems with cognition, symptoms similar to strokes like paralysis
  • Nerves Tingles or feeling of numbness losing strength, sensation in hands

In the most severe instances, the disease causes blood vessels to shutdown, which means that blood cannot flow through. This may result in the process of stenosis (blockage). If it is severe vasculitis may cause organ damage or even death.

The treatment options are according to what the extent of illness and the organs that are affected. Patients with vasculitis that is severe are treated with corticosteroids such as prednisolone as a way to lessen inflammation in blood vessels. Other immunosuppressive medicines are typically employed in conjunction with steroids. 6

One Word from Very Well

In the majority of instances, autoimmune disorders aren’t fatal, and those suffering from an autoimmune condition are likely to live for a long time.

There are a number of autoimmune illnesses that could be fatal or cause life-threatening complications. However, they are extremely rare. If you’re worried about your health, or are concerned whether you have an autoimmune disorder consult your doctor.

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